Bioassay of 29 Alkylatlng Chemicals by the Pulmonary-Tumor Response In Strain A Mice
Identifieur interne : 003D27 ( Main/Exploration ); précédent : 003D26; suivant : 003D28Bioassay of 29 Alkylatlng Chemicals by the Pulmonary-Tumor Response In Strain A Mice
Auteurs : M. B. Shimkin [États-Unis] ; J. H. Weisburger [États-Unis] ; E. K. Weisburger [États-Unis] ; N. Gubareff [États-Unis] ; Valentina Suntzeff [États-Unis]Source :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 1966.
Abstract
Twenty-nine alkylating agents, including aromatic and aliphatic nitrogen mustards, aziridines, epoxides, and methanesulfonates, were examined for their ability to induce primary lung tumors in strain A mice in a 39-week test, after 12 intraperitoneal injections given in a 4-week period. Four or more dose levels were used for each chemical. A mathematical relationship between number of tumors and dose level was derived for each compound, which permitted an estimation of its potency at any dose. The aromatic-type nitrogen mustards, especially uracil mustard, L-phenylalanine mustard, and chlorambucil, were most active in producing lung tumors, while aliphatic mustards, aziridines, and methanesulfonates were somewhat less effective. In any given series of compounds, those with structures simulating a naturally occurring substrate were more active. The effectiveness of the aromatic mustards may be related to the greater stability of the reactive intermediate. However, other factors such as detoxification, transport, and solubility are also involved. The carcinogenic activity of these alkylating agents was compared with the activity of a series of other carcinogens and related compounds. The potency of these compounds to induce lung tumors was not related to their carcinostatic effect on the transplantable L1210 leukemia.
Url:
DOI: 10.1093/jnci/36.5.915
Affiliations:
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Four or more dose levels were used for each chemical. A mathematical relationship between number of tumors and dose level was derived for each compound, which permitted an estimation of its potency at any dose. The aromatic-type nitrogen mustards, especially uracil mustard, L-phenylalanine mustard, and chlorambucil, were most active in producing lung tumors, while aliphatic mustards, aziridines, and methanesulfonates were somewhat less effective. In any given series of compounds, those with structures simulating a naturally occurring substrate were more active. The effectiveness of the aromatic mustards may be related to the greater stability of the reactive intermediate. However, other factors such as detoxification, transport, and solubility are also involved. The carcinogenic activity of these alkylating agents was compared with the activity of a series of other carcinogens and related compounds. The potency of these compounds to induce lung tumors was not related to their carcinostatic effect on the transplantable L1210 leukemia.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Missouri (État)</li></region></list><tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Shimkin, M B" sort="Shimkin, M B" uniqKey="Shimkin M" first="M. B." last="Shimkin">M. B. Shimkin</name></region><name sortKey="Gubareff, N" sort="Gubareff, N" uniqKey="Gubareff N" first="N." last="Gubareff">N. Gubareff</name><name sortKey="Suntzeff, Valentina" sort="Suntzeff, Valentina" uniqKey="Suntzeff V" first="Valentina" last="Suntzeff">Valentina Suntzeff</name><name sortKey="Weisburger, E K" sort="Weisburger, E K" uniqKey="Weisburger E" first="E. K." last="Weisburger">E. K. Weisburger</name><name sortKey="Weisburger, J H" sort="Weisburger, J H" uniqKey="Weisburger J" first="J. H." last="Weisburger">J. H. Weisburger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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